Ophumelele iNtetho kaMongameli: Intetho yeNtetho kaStanley Fahn | iCongress ka-2026

UBJ Jeon ngumlawuli we-BJ Center for Comprehensive Parkinson Care and Rare Movement Disorders kwiSibhedlele iHyundae, uprofesa osele ekhulile kwiYunivesithi yeSizwe yaseSeoul, kwaye ungusihlalo wekomiti yokulungiselela iNgqungquthela yeHlabathi eSeoul.

Kwaye le yinxalenye yochungechunge lwe-MDS Congress. Uza kunika, njengoko benditshilo, iStanley Fahn Award Lecture kwiCongress. [00:01:00] Siyavuyisana noGqr. Jeon, kwaye enkosi kakhulu ngokujoyina nathi namhlanje.

UProfesa BJ Jeon: Enkosi kakhulu, kwaye molweni nonke. Lilungelo elikhulu ukuba lapha kwi-podcast ye-MDS namhlanje. Ukufumana iStanley Fahn Lecture Award lilungelo elikhulu elindishiya ndithobekile kakhulu. Okuyenza ikhetheke ngakumbi kukuba iNkomfa yaMazwe ngaMazwe yalo nyaka ibanjelwe apha kwilizwe lam, eSeoul. Ndonwabile kakhulu ukwabelana ngohambo lwam, unxibelelwano lwam olunzulu nelifa likaGqr. Fahn, kunye nomsebenzi wethu wamva nje kwi-GCH1 noluntu lwehlabathi olujongene neengxaki zokunyakaza namhlanje. Enkosi ngokundimema.

UDkt. Sara Schaefer: Ngoku, ndiyazi ukuba eli lilungelo lakho ngenxa yobudlelwane bakho noStanley Fahn. Lithiywe ngoDkt. Fahn, umntu odumileyo, njengoko sonke sisazi, kwicandelo leengxaki zokunyakaza. Wena ngokwakho uchithe ixesha kwiYunivesithi yaseColumbia njengomfundi phantsi kukaDkt. [00:02:00] Fahn kwaye wafunda lukhulu kuye, ndiqinisekile.

Ixesha lakho apho layitshintsha njani indlela yakho yokusebenza njengogqirha nanjengomphandi?

UProfesa BJ Jeon: Ukufumana eli bhaso kundichukumisa kakhulu kwaye kunentsingiselo kum. Ixesha lam njengomfundi kwiYunivesithi yaseColumbia layichaza ngokupheleleyo indlela yam. Ngaphambi kokuba ndiye eColumbia, ndandijonga iingxaki zokunyakaza ikakhulu ngeencwadi zesikolo. Kodwa ukusebenza apho phantsi kokuzinikela okukhulu kwabasebenzi kwaye uGqr. Fahn wandifundisa indlela yokujonga isigulana esingasemva kwesi sifo.

IColumbia yayiyindawo apho ukugqwesa kwezonyango kwadibana nomdla onzima wesayensi. Kwandifundisa ukuba ndingaze ndiyamkele impendulo yokugqibela ethi "asazi". Yonke imeko enzima esiyixoxe ngayo kwividiyo yangoLwesibini yayingeyonto nje enzima ukuyisombulula. Yayingumsebenzi onzima ukuwuthatha ndibuyele kwilebhu. Loo mxube weemvakalelo [00:03:00] kunye nophando olusecaleni kwebhedi kwayila yonke indlela yomsebenzi wam.

UDkt. Sara Schaefer: Kuvakala ngathi uGqr. Fahn wayekuphefumlela ngokwenene, njengoko wayenjalo kwabaninzi, kwaye usaqhubeka enjalo. UGqr. Fahn waziwa ngegalelo lakhe lesayensi, ewe, kwaye nangokuba ngumcebisi wakhe kwabanye abafundi kwiminyaka emininzi edlulileyo. Wakuchaphazela njani wena njengomfundisi, kwaye uqhuba njani ulwalathiso lwakhe kumsebenzi wakho kunye nendlela oqeqesha ngayo isizukulwana esilandelayo sabafundi?

UNjingalwazi BJ Jeon: UGqr. Fahn wayenobu bukho bukhethekileyo, kodwa njengomcebisi, wayenobubele kwaye enomonde kakhulu. Akazange anike iimpendulo nje kuphela, wasifundisa indlela yokucinga nendlela yokubuza imibuzo efanelekileyo. Ndisawakhumbula amazwi akhe akhuthazayo xa iprojekthi ingahambanga njengoko bekucwangcisiwe. Wandifundisa ukuba ukungaphumeleli kuphando yidatha nje esikhokelela kwicala elingcono [00:04:00].

Olu monde lwalubaluleke kakhulu kum kamva xa ndandijonga kwiingxaki zesifo sikaGCH1 kunye nesifo sikaParkinson, esasifuna iminyaka yokunyamezela. Ngoku, njengomfundisi-ntsapho eKorea, ndizama ukuphinda ilifa lakhe. Ndixelela abanye abafundi bam kunye nabafundi into efanayo neyafundiswa nguGqr. Fahn ngokungangqalanga, "Mamelani isigulana, kwaye ningoyiki ukulandela iingcamango ezingaqhelekanga."

Ngaphezu koko, kweli xesha langoku lokuvalwa kwemida, bendiya kucamngca ngembono yakhe yehlabathi. UGqr. Fahn wayesoloko egxininisa uthando lwakhe lokuqeqesha abafundi bamanye amazwe, esazi ukuba baza kubuyela kumazwe abo basekhaya baze banikele apho kukho imfuneko enkulu yezonyango. Ndizama ngamandla ukuqhubeka nefilosofi yakhe kwiSibhedlele seYunivesithi yeSizwe saseSeoul [00:05:00], apho samkela khona abafundi abaninzi bamanye amazwe, kuquka nabafundi abatyeleleyo beTravel Grants.

Ndikholelwa ukuba ukudlulisela loo mngxuma wolwazi lwehlabathi kunye nokhathalelo lokwenene kwisizukulwana esilandelayo, yeyona ndlela ilungileyo yokuhlonipha ubunkokeli bakhe.

UDkt. Sara Schaefer: Kundikhumbuza into endiyibonileyo ukuba eyona miphumo ilungileyo yesayensi kukungatsho ukuthi "Eureka!" kuba uqinisekisa ingcamango yakho, kodwa uthi "Huh, kuyahlekisa oko," uze ujonge ukuba kutheni into ethile ingazange ihambe ngendlela obucinga ukuba iza kuhamba ngayo.

UProfesa BJ Jeon: Ewe, kulungile oko.

UDkt. Sara Schaefer: Kwaye ewe, uDkt. Fahn uchithe umsebenzi wakhe edibanisa abantu neMovement Disorder Society, kwaye ndiza kujonga nje esinye seziqendu zethu zakudala apho ndidlan’ udliwanondlebe noDkt. Fahn malunga nemvelaphi yeMovement Disorders njengengcali kunye neMovement Disorder Society.

Ibiludliwanondlebe olundivule amehlo, kwaye [00:06:00] Ndicebisa ukuba abaphulaphuli bethu babuyele umva baze baphulaphule. Xa ndijonga uhambo lwakho ukususela kwiintsuku zakho zobudlelwane ukuya ekunikezeni le ntetho epheleleyo, impumelelo enkulu kunye nodumo kwilizwe lakho, ingasathethwa ke, yaseSeoul, eKorea, yeyiphi ifilosofi okanye umdla oyintloko okukugcine uqhuba yonke le minyaka?

UNjingalwazi BJ Jeon: Ukuba kufuneka ndikhethe ifilosofi enye eyintloko, yeyona nto iphambili ekuqwalaselweni kweklinikhi, into uGqr. Fahn ayifakile kwi-DNA yam. Ndisakhumbula kakuhle ndihleli kwiividiyo zakhe zangoLwesibini kusasa ngexesha lobudlelwane bam. Ngenye intsasa, sibukele ividiyo yesigulana esine-dopa-response dystonia.

Ukubona loo mpendulo imangalisayo, phantse ingummangaliso kwi-L-dopa kundichulumancisile kakhulu. Yayilixesha elibalulekileyo eliye laqhuba uphando lwam ukusukela ngoko. Loo mdla nge-DRD kunye nendlela yokwenziwa kwe-dopamine esisiseko [00:07:00] yiyo eyandikhokelela kuthando lwam lobomi bonke ngendima ye-GCH1 kwisifo sikaParkinson. Ndandifuna ukuthatha olo qwalaselo lubukhali lweklinikhi ecaleni kwebhedi yaseColumbia ndiluguqulele kwithiyori enentsingiselo. Ukuma apha kwilizwe lam, eSeoul, ukuze ndinike le ntetho epheleleyo, ndiphethe umdla owavutha kwividiyo yaseNew York kwiminyaka emininzi eyadlulayo uvakala ngathi ngumzuzu omhle opheleleyo.

UDkt. Sara Schaefer: Njengomntu obekade ebandakanyeka kakhulu kwi-International Parkinson and Movement Disorder Society, uyijonga njani indima yentsebenziswano yehlabathi ekufumaneni impumelelo enkulu elandelayo kwi-move disorders? Oku akupheleli nje ekufundiseni uluntu lwe-move disorders lwehlabathi, kodwa nakwintsebenziswano kwicala lophando.

UProfesa BJ Jeon: Isayensi ayinakukwazi ukuqhubela phambili yodwa kwaye ifuna inethiwekhi yehlabathi. Enyanisweni, umsebenzi wam [00:08:00] kwi-GCH1 kunye nesifo sikaParkinson ngumphumo othe ngqo wale mizamo yokusebenzisana yamazwe ngamazwe ngokusebenzisana ngokusondeleyo neenethiwekhi zehlabathi ezifana ne-GEoPD kunye ne-GP2. Ngokuhlanganisa amatyala angaqhelekanga avela kwihlabathi liphela, sikwazile ukuba nedatha ekungekho ziko linye elinokuba nayo lodwa.

Yingakho inkqubo ye-MDS ibaluleke kangaka. Ukuze kufunyanwe unyango olukhulu olulandelayo, intsebenziswano yehlabathi ayisekho yokuzikhethela, yiplani.

UDkt. Sara Schaefer: Kwaye abaphulaphuli bethu kuza kufuneka baye kwiNgqungquthela ye-MDS baye kwiNtetho yakho yeMbasa kaStanley Fahn emangalisayo ukuze beve ngeziphumo zentsebenziswano yehlabathi ne-GCH1 kwisifo sikaParkinson nezinye izifo. Kodwa kuyathakazelisa kakhulu ukuva amabali emvelaphi yabantu abenza umahluko omkhulu kweli candelo.

Ngaba unazo naziphi na izimvo zokugqibela ngabaphulaphuli bethu?

UNjingalwazi BJ Jeon: Ingcinga yam yokugqibela ingaba ngumyalezo oya kwisizukulwana esilandelayo [00:09:00] soogqirha nabaphandi abaphulaphule oku. Ungaze uwajongele phantsi amandla okujonga izigulane zakho ngokusondeleyo. Njengoko uGqr. Fahn wayesoloko esifundisa, impendulo esiyifunayo kwilebhu phantse rhoqo iqala ngoqwalaselo olubukhali lweklinikhi ecaleni kwebhedi.

Ndifuna ukubulela kakhulu oogxa bam ababalaseleyo, kunye nabasebenzi bam bamanye amazwe kwi-GEoPD kunye ne-GP2. Le mpumelelo yeyethu sonke. Kwaye ekugqibeleni, ndiyanibulela kwakhona kwi-MDS, kwaye andikwazi kulinda ukunamkela nonke eSeoul entle kwi-MDS ka-2026. Siza kubonana kungekudala.

UDkt. Sara Schaefer: Ndiza kukubona apho. Ndilangazelela kakhulu. Enkosi kakhulu, kwaye kwakhona, ndiyavuyisana noDkt. Jeon ngale mbeko inkulu.

UProfesa BJ Jeon: Enkosi kakhulu. [00:10:00]