Udidi lwe-corticobasal syndrome olusekelwe kwi-biomarker 

---

I-Corticobasal syndrome (CBS) sisifo esichazwe ngokwezonyango esineengxaki zokunyakaza okuqhubekayo kunye neempawu ze-cortical, ezinokubangelwa ziintlobo ngeentlobo zezifo ezichazwe ngokwe-neuropathologically. I-CBS idla ngokunxulunyaniswa ne-4-repeat tauopathies (4RTs), kubandakanya i-progressive supranuclear palsy (PSP) kunye ne-corticobasal degeneration, okanye i-mixed 3-repeat / 4-repeat tauopathy Alzheimer's disease (AD). Nangona kunjalo, i-Lewy-type α-synucleinopathies (LTS), i-TDP-43 proteinopathies, okanye i-mixed pathologies nazo zingabonakala njenge-CBS. Sekunjalo ukubaluleka kweklinikhi kwe-pathologies ezahlukeneyo ezisisiseko se-CBS akukaqondwa kakuhle. Ke ngoko, uphando lwangoku lujolise ekuhleleni izigulane ze-CBS ngokweemolekyuli ngokusebenzisa ii-biomarkers ze-amyloid (Aβ), i-Tau, kunye ne-α-synuclein (αSyn), okuvumela ukuba kubekho ulwahlulo oluncinci kwi-in vivo. 

Senze uphando olujoliswe kwi-cohort olubandakanya izigulana ezingama-50 ze-CBS ezazijongwe ngokwezonyango kwi-LMU University Hospital eMunich. Uhlalutyo lwe-biomarker luquke imilinganiselo ye-cerebrospinal fluid (CSF) ye-Aβ42 kunye ne-Aβ42/40 ratios, [18F]Flutemetamol β-amyloid-PET, [18F]PI-2620 Tau-PET, kunye novavanyo lwe-CSF αSyn seed amplification. I-Neurofilament light chain (NfL) kwi-CSF isebenze njengophawu olungelulo olucacileyo lwe-neurodegeneration. I-Biomarker positivity okanye i-negativity ivumele ukwahlulwahlulwa kwe-CBS kumaqela amathandathu, ichonga izinto ezinesifo ezisekelwe kwi-Aβ, Tau, kunye ne-αSyn combinations.  

Iziphumo zethu zityhile ukuxhaphaka okuphezulu kweTau positivity, apho i-90% yezigulane ze-CBS zineTau-positive, ngelixa i-Aβ kunye ne-αSyn positivity zibonwe kwi-28% kunye ne-24% yamatyala, ngokulandelelana. Ukwahlulahlulwa ngokwezigaba yi-biomarker-defined disease entities kubonise ukuba i-52% yeemeko ze-CBS zihambelana ne-4RT, i-18% ene-AD, i-10% kunye nokuvela kwe-AD kunye ne-LTS, i-10% ene-4RT kunye ne-LTS, kunye ne-4% ene-LTS ezizimeleyo. I-6% ayikachazwanga. I-αSyn-positivity yayixhaphake kakhulu kwiimeko ze-CBS ezine-AD eqikelelweyo (36%), xa kuthelekiswa nezo zine-4RT eqikelelweyo (16%). Ngokwezonyango, i-Aβ-positivity yayinxulunyaniswa nokukhubazeka kwengqondo okunamandla kwiMontreal Cognitive Assessment kunye neDementia Apraxia Test. I-Tau positivity yayinxulunyaniswa neempawu zokunyakaza ezinzima kodwa ayizange ibonise mpembelelo ibalulekileyo kumazinga okuqhubekeka kwesifo. Ngokwahlukileyo koko, izigulane ezine-αSyn positive zibonakalise iimpawu ezincinci zokunyakaza, amanqaku aphantsi esikali sokulinganisa se-PSP, kunye nokuqhubela phambili okucothayo ngokuhamba kwexesha, kunye namanqanaba aphantsi kakhulu esiseko se-CSF NfL. 

Uphononongo lwethu lugxininisa ukungafani kweemolekyuli ze-CBS, lugxininisa amandla okwahlulahlula okusekelwe kwi-biomarker ukuphucula ukuchaneka kokuxilongwa kunye nokukhokela unyango olujoliswe kulo. 

Funda iphepha