Iqela loFundo lwe-Spasticity
Ngaba unemibuzo? Nxibelelana noMnxibelelanisi wabasebenzi be-MDS beqela, uMolly Kadrich, ku-mkadrich@movementdisorders.org
Ugunyaziso/ Injongo:
- Ukuxhasa ukuba i-spasticity luphawu lwe-spastic paresis, ukuphazamiseka kwentshukumo ye-spastic enyangekayo.
- Ukunceda ukuphuhlisa unyango kwabo bakhubazekileyo ngenxa paresis spastic ukubuyisela umsebenzi osebenzayo amalungu omzimba achaphazelekayo
- Ukuphuhlisa "Isikali esiManyeneyo sokuReyitha kwi-Spastic Paresis" kulingo lwezonyango
- Ukuchaza, ukubonakalisa kunye nokuseka ubuninzi be-post-stroke spasticity, i-Hereditary Spastic Paraparesis (HSP) kunye ne-spastic cerebral palsy.
- Ukuseka irejistri yezigulane zehlabathi jikelele ye-HSP edityaniswe neendawo esele zifumaneka ngezifo ezithile.
- Ukusebenzela ekuphuhliseni ukuvumelana kwezizwe ngezizwe ukukhuthaza ukuxilongwa, ukuchongwa, ukuhlelwa, ukusasazwa, uphando kunye neemvavanyo zoguqulelo lwe-spasticity paresis njengokuphazamiseka kwentshukumo.
- Ukuphuhlisa, ukuguqulela kunye nokungqinisisa ikharityhulamu yemfundo ethile ye-post-stroke spasticity, i-spastic CP kunye ne-HSP
- Ukuphuhlisa i-Good Clinical Practice (GCP) izikhokelo zokuxilongwa, unyango olungelulo olwamayeza kunye nonyango lwe-pharmacological
Okungakumbi malunga neQela loFundo lwe-Spasticity
Eli qela lophononongo lenziwe ukuphuhlisa uphando lwentsebenziswano lwamazwe ngamazwe kwintsimi ye-spasticity, kubandakanywa nasemva kwe-stroke. I-post-stroke i-spasticity ikhula ngokukhawuleza ekuxhaphakeni kumazwe amaninzi, mhlawumbi aphuhlisiwe okanye asakhulayo. Phakathi kwabo, amazwe aseAsia aya kubandezeleka kakhulu, ngenxa yokuqhuma kwabo abantu abadala kwixesha elizayo (1) (Kaji Neurology 2015).
Ukuxhaphaka kwe-spasticity emva kwe-stroke kuqikelelwa ukuba yi-30-49% yabasindileyo, kwaye, i-spasticity ye-stroke iyona nto ibangela ukukhubazeka eJapan, ngoku inezinga eliphezulu lokuguga phakathi kwamanye amazwe.Iindleko zentlalo yokunyamekela abasindileyo be-stroke zinyuka, kunye nezi gulane zilahlekelwa ukuzimela kunye nokuzithemba. Amanyathelo onyango anjengenaliti yetyhefu ye-botulinum ayafumaneka ngoku kwamanye amazwe(2), kodwa eyona ndlela ingcono yokusetyenziswa kwezonyango ayikaphononongwa. Ukongeza, i-spasticity yimbangela enkulu yokukhubazeka kwezinye izifo ze-neurological ezifana ne-hereditary spastic paraplegias (HSPs) kunye ne-cerebral palsy (CPs).
Kukho ingxabano malunga nokuba i-spasticity yinxalenye yokuphazamiseka kwentshukumo okanye cha. Ezinye iimpawu ze-physiological zabelwana nge-dystonia, ngokuba kukho ukubambisana kwe-agonist kunye nezihlunu ezichasayo (3) kunye nomsebenzi osebenzayo unokubuyiswa kwimilenze enzima ye-spastic usebenzisa i-botulinum injection ye-toxin (4-6) (Kaji 2013, Kaji et al. 2010), kodwa i-dystonia ihluke kwi-spasticity kwi-spasticity leyo i-spastic ehlala ibonwa kwi-spastic. Iindlela zonyango ezisetyenziselwa ukunyanga i-dystonia zithembisa ukunyanga inani elikhulu labantu abane-stroke. Isiseko, kunye nezifundo zeklinikhi ze-pathophysiology, ukuxilongwa kunye nonyango ziyafuneka.
Ngenkqubela phambili yakutsha nje kwi-neurorehabilitation, ezinye iirobhothi (umz. i-ReWalk, iHybrid Assisted Limb) zivavanyelwa ukuvunywa kwayo njengecebo lonyango(7), kodwa azikhange ziphumelele ngaphandle kokuba zidityaniswe nenaliti ye-botulinum.
Okwangoku, iQela lokufunda nge-Spasticity lijolise ekuhlanganiseni abaphandi, amaqela ezigulane, iingcali zempilo kunye namashishini; kunye nokukhuthaza uphando ukuze kuphuculwe ukuqonda kwe-spasticity njengengxaki yokunyakaza okunyangekayo kunye nokuphonononga iindlela zonyango zonyango lwe-toxin ye-botulinum yodwa okanye ukusetyenziswa kwayo ngokudibeneyo kunye nokubuyisela. Umzamo onjalo wamazwe ngamazwe udibana nomsebenzi we-MDS kunye nentsebenziswano ne-WHO, kufuneka ube negalelo elikhulu kwiimfuno zonyango zentlalo ezihlala zinyuka njengoko ukuguga kukhawuleza kumazwe amaninzi.
iiprojekthi
ubunkokheli
Sihlalo
UJörg Wissel
Usekela-Sihlalo
UJean-Michel Gracies
Ikomiti eqhubayo
I-Bo Biering-Sørensen
Nevine El Nahas
USimon Ernest
UMartina Hoskovcova
URobert Jech
UMolly Kadrich
IMacarena Menares Koppe
UMaud Pradines
Raymond Rosales
UDavid Simpson
Ucaphulo
- Kaji R. Asian neurology kunye nestroke. I-Neurology. 2015;84(10):1051-2.
- Lim EC, Seta RC. Ukusetyenziswa kwe-toxin ye-botulinum kwiklinikhi ye-neurology. Nat Rev Neurol. 2010;6(11):624-36.
- Ubabalo JM. Iziphumo zePhysiological of botulinum toxin kwi-spasticity. Mov Disord. 2004;19 Inkxaso 8:S120-8.
- I-Kaji R. Isenzo esithe ngqo se-central ye-intramuscularly injected botulinum toxin: ingaba yingozi okanye inenzuzo? J Physiol. 2013;591(4):749.
- Kaji R, Osako Y, Suyama K, Maeda T, Uechi Y, Iwasaki M, Group GSKSS. Uhlobo lwetyhefu ye-botulinum A kwi-post-stroke ye-spasticity yamalungu aphezulu. Curr Med Res Opin. 2010;26(8):1983-92.
- Kaji R, Osako Y, Suyama K, Maeda T, Uechi Y, Iwasaki M, Group GSKSS. I-botulinum ye-toxin uhlobo lwe-A kwi-post-stroke ye-spasticity ephantsi yomlenze: i-multicenter, i-double-blind, isilingo esilawulwa yi-placebo. J Neurol. 2010;257(8):1330-7.
- Esquenazi A, Mayer N, Lee S, Brashear A, Elovic E, Francisco GE, Yablon S, Group PS. Ubhaliso lwesigulana lweziphumo kukhathalelo lwe-spasticity. NdinguJ Phys Med Rehabil. 2012;91(9):729-46.