Iqela leSifundo seAtrophy yeeNkqubo ezininzi
Ngaba unemibuzo? Nxibelelana no-Amber Flatland, uMnxibelelanisi wabasebenzi be-MDS beqela, ku-aflatland@movementdisorders.org
Goals
Siceba ukuphuhlisa iseti yedatha eqhelekileyo, kubandakanywa izikali eziqinisekisiweyo zesifo ezichanekileyo zokufumana idatha ehambelanayo. Okwesibini, sijonge ukusungula ubhaliso lwezigulane lwe-MSA lwehlabathi. Okwesithathu, siya kuphehlelela izifundo ezijolise ekufunyanweni kweempawu zokuxilonga kunye ne-surrogate (bio) kunye nokumiselwa kwesiseko sendalo esingqongileyo kunye nemfuzo. Ekugqibeleni, siya kuphuhlisa izikhokelo zokuvumelana (ezona zilungileyo) kumgangatho wokunyamekela kwi-MSA (ngokusekelwe kwimigaqo yobungqina beyeza).
Sichaze ezi njongo zilandelayo:
- Ukuseka ubhaliso lwezigulane zehlabathi
- Ukuseta ibhanki yebhayomaterial enatyisiweyo kwaye ngaloo ndlela kucaciswe iinkqubo zokusebenza ezisemgangathweni ukulungelelanisa igazi, iCSF kunye nesampulu yezicubu zengqondo.
- Ukuchonga indawo yomngcipheko wemfuza ye-MSA kusetyenziswa izifundo zombutho omkhulu we-genome-wide
- Ukuphuhlisa, ukuguqulela kunye nokuqinisekisa imilinganiselo eyongezelelweyo ye-MSA-specific rating scales
- Ukuchaza kunye nokuqinisekisa abamakishi benkqubela phambili yokuzimela
- Ukuchaza kunye nokuqinisekisa i-MRI kunye ne-imaging esebenzayo yokumakisha i-surrogate progression markers
- Ukuphuhlisa izikhokelo zolingo longenelelo
- Ukuphuhlisa iindlela ezingcono kakhulu (ezisekelwe kubungqina) izikhokelo ze-pharmacologic kunye nonyango olungelulo lwe-pharmacologic.
- Ukuphanda iindlela ze-MSA ze-pathophysiological kunye nokukhusela iikhompawundi zabaviwa kwiimodeli ze-MSA zangaphambili
Kufuneka Iqela Elifundisiswayo Entsimini
I-Multiple system atrophy (MSA) yintlupheko yentshukumo enqabileyo kwaye engapheliyo kunye nokuqikelelwa kwe-4 / 100,000 yabantu (Schrag 1999). Okwangoku akukho nyango lukhoyo lokunciphisa kakhulu iimpawu zemoto kunye nokuzimela okanye ukuguqula indlela yendalo yesi sifo. Ukongezelela, akukho zikhokelo ezivunyiweyo ngokubanzi kwizicwangciso zonyango lweempawu ezikhoyo.
Ukuza kuthi ga ngoku, uphando lwezonyango lwe-MSA luthintelwe lizinga lokuxhaphaka elisezantsi elithintela iisayithi zophando zomntu ngamnye ekufundeni amanani aneleyo ezigulane. Ke ngoko, umzamo olungelelanisiweyo kwinqanaba lamazwe ngamazwe uyafuneka ukuqhubela phambili uphando lwe-MSA kwinkalo yokufunyanwa kwe-biomarker, ukuxilongwa kwangoko, inkcazo yesiseko sofuzo kunye nophuhliso lwechiza lokuguqulela. Ngako oko, isikhokelo solawulo sophando lwe-MSA lwentsebenziswano yehlabathi siyafuneka.
ubunkokheli
Sihlalo
Alessandra Fanciulli
Usekela-Sihlalo
Alexander Pantelyat
Ikomiti eqhubayo
Erwan Bezard
Viorica Chelban
UFlorin Gandor
Tanya Gurevich
Taku Hatano
Vikram Khurana
U-Eun Kim oselula
UHan-Joon Kim
UKatherine Longardner
UNikolaus McFarland
Nkechi Obianozie
UMaria Teresa Pellecchia
Samia Ben Sassi
UManu Sharma
UWolfgang Mvumi
Amaphepha apapashiweyo
Ndiyifumanisa Njani i-Atrophy yeeNkqubo ezininzi-Ithala levidiyo kwiiNkcukacha zeKlinikhi kunye neMifanekiso
- Multirogram System Atrophy
Uhlalutyo lweGenome lokulandelelana Chonga iNoveli yoMngcipheko weLoci yeAtrophy yeeNkqubo ezininzi
- Multirogram System Atrophy
Iimpawu ezichazwe ngesigulana kwi-Global Multiple System Atrophy Registry
- Multirogram System Atrophy
Iikhrayitheriya zoMbutho we-Movement Disorder for the Diagnosis of Multiple System Atrophy
- Multirogram System Atrophy
- Inkqubela phambili yokuHamba kwePransukraine (PP)
Ukunciphisa i-oligodendrocyte exosome secretion kwi-atrophy yenkqubo eninzi ibandakanya ukungasebenzi kwe-SNARE
- Multirogram System Atrophy
Iimbonakalo
Amanqaku namabali malunga neqela.