Iqela loFundo lokungcangcazela
Ngaba unemibuzo? Nxibelelana noLiliana De Leon, uMnxibelelanisi wabasebenzi be-MDS beqela, ku-ldeleon@movementdisorders.org.
malunga
Iqela leSifundo seTremor (TSG) lavela kwiTask Force on Tremor, eyagqiba umsebenzi wayo ngoJuni 2017. ITask Force yaphonononga izikali zokulinganisa ezipapashiweyo. 1 kunye neetransducers 2 zokulinganisa ukungcangcazela kwaye yaphuhlisa iskimu sokwahlulahlula esihlaziyiweyo sokungcangcazela. 3 Uphononongo olusekelwe kubungqina lwezonyango ezipapashiweyo zokungcangcazela okubalulekileyo lwenziwe. 4 Ngokusekelwe kulo msebenzi, iinjongo ezilandelayo ze-TSG zichongiwe.
iinjongo
1. Ukungcangcazela okunzulu kwephenotyping
I-phenotyping ecwangcisiweyo, enzulu yezigulane ezine-monosymptomatic tremor disorders (umzekelo, ukungcangcazela okubalulekileyo) kuyadingeka. I-TSG ke ngoko iphuhlisa isixhobo sovavanyo lwe-ordinal esiza kukhokela oogqirha kwiphenotyping yenyikima enzulu, ukuze kwahlulwe ukungcangcazela okubalulekileyo nokungcangcazela okubalulekileyo kunye nezinye iindlela zokungcangcazela ezidla ngokuphazama njengokungcangcazela okubalulekileyo. Isixhobo sovavanyo siya kubamba iimpawu ezifihlakeleyo okanye ezithandabuzekayo ze-dystonia, i-myoclonus, i-parkinsonism kunye ne-ataxia. Iprotocol yevidiyo iyaphuhliswa ngokubambisana nesi sixhobo. Ukuqinisekisa olu vavanyo kunye neprotocol yevidiyo, ilungu ngalinye le-TSG liya kuvelisa uvavanyo lwevidiyo lwezigulana ezithathu: ukungcangcazela okubalulekileyo, ukungcangcazela okubalulekileyo kunye ne-syndrome edibeneyo yokungcangcazela ethe yanikezela ngesikhalazo esisodwa sokungcangcazela (monosymptomatic tremor disorder). Injongo ephambili kukubandakanya esi sixhobo sovavanyo kunye neprotocol yevidiyo kwi-database ye-REDCap esekelwe kwiwebhu enokusetyenziswa ngokubambisana nezifundo zophando lweklinikhi.
2. Uphuhliso lwesikali sokungcangcazela
Isikali sobunzima bokungcangcazela kwe-Othostatic
Kuphononongo lwethu lwangaphambili lwezikali zovavanyo lokungcangcazela ezikhoyo, kufunyenwe ukuba akukho sikali siqinisekisiweyo sokungcangcazela kwe-orthostatic. 1 Unyango lwale meko ingaqhelekanga lujongwa ngamayeza nangotyando, kwaye kuphuhliswe isikali esiqinisekisiweyo sokungcangcazela kwe-orthostatic. 5
Isikali sokulinganisa ukungcangcazela okudityanisiweyo
Isikali siyafuneka esibamba okuqhelekileyo (intshukumo yentshukumo) kunye ne-atypical (umzekelo, ukungcangcazela kokuphumla, ukungcangcazela kwelungu elisezantsi elibonakalayo) kwizigulana ezinokungcangcazela okuyimfuneko kunye nokungcangcazela okubalulekileyo kunye. Siphuhlisa isikali esitsha esakhela phezu kwamandla eFahn-Tolosa-Marín kunye ne-Essential Tremor Rating Assessment Scale (TETRAS). Esi sikali siya kuba lelinye lebhetri yezikali kuvavanyo lweklinikhi lokungcangcazela.
3. Izixhobo ezisetyenziswayo zokungcangcazela
Imiba ethile yokungcangcazela kukholelwa ukuba iluncedo ekwahluleni ukungcangcazela okuyimfuneko kokunye ukungcangcazela (umzekelo, ukungcangcazela kwedystonic kunye nerhythmic cortical myoclonus). Nangona kunjalo, ezi mpawu zokungcangcazela (umzekelo, ukungahambi kakuhle kwi-amplitude kunye nesingqisho, i-axis eguquguqukayo yokujikeleza, ukuma kwentloko okanye umlenze) kunzima kakhulu ukuhlola ngokuhlolwa kweklinikhi. Sikholelwa ukuba kukho indima yee-transducers ezishukumayo, uhlalutyo lwevidiyo yekhompyuter, kunye nezinye iindlela ze-electrophysiologic kuphawu lokungcangcazela. Sicinga ukuba iindlela ezinjalo zisetyenziswa kwiphenotyping enzulu yezigulane ezingcangcazelayo.
4. Ugcino-lwazi olusekelwe kwi-Web-based tremor
I-TSG inenjongo iyonke yokukhuthaza ubunzulu obukhulu kunye nokumiswa emgangathweni kwiphenotyping yezigulana ezinokuphazamiseka kokungcangcazela, ngakumbi ukuphazamiseka kwe-monosymptomatic yenyikima efana nokungcangcazela okuyimfuneko. Izikali eziphuhliswe yi-TSG ziya kufakwa kwi-web-based tremor database eya kuba nedatha yedatha efana ne-Dystonia Coalition database. Lo vimba wogcino-lwazi uya kudityaniswa nogcino lweevidiyo zesigulane kunye noovimba beesampuli zeDNA kuphando.
5. Uphononongo lokunyamezela i-DBS
U-Alfonso Fasano kunye no-Rick Helmich bakhokela kuphononongo lonyamezelo kwizigulana ezinyangwa ngovuselelo olunzulu lobuchopho lokungcangcazela. I-phenotype yeklinikhi, indawo ye-electrode, kunye nabamakishi be-electrophysiologic bavavanywa njengento enokwenzeka yokuqikelela umphumo wonyango.
ubunkokheli
Aasef Sheikh
Sihlalo
Alfonso Fasano
Sihlalo
Ikomiti eqhubayo
Alberto Albanese
Kailash Bhatia
Matteo Bologna
UDaniel Di Luca
URoberto Erro
URick Helmich
UFranziska Hopfner
UFariha Jamal
Yusuf Jamnagerwalla
Hyder Jinnah
Sheng-Han Kuo
UWilliam Ondo
I-Ming-Kai Pan
Sanjay Pandey
Pattamon Panyakaew
U-Mohamed Salim
Petra Schwingenschuh
ULudy Shih
Ucaphulo
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2. Haubenberger D, Abbruzzese G, Bain PG, et al. Uvavanyo lokungcangcazela olusekwe kwi-Transducer. Mov Disord 2016;31(9):1327-1336.
3. Bhatia KP, Bain P, Bajaj N, et al. Ingxelo yeMvumelwano malunga nokuhlelwa kweenyikima. ukusuka kwiqela elisebenzayo kwinyikima yeHlabathi yeParkinson kunye neMovement Disorder Society. Mov Disord 2018;33(1):75-87.
4. Ferreira JJ, Mestre TA, Lyons KE, Benito-Leon J, Tan EK, Abbruzzese G, et al. Uphononongo olusekwe kubungqina be-MDS bonyango lokungcangcazela okubalulekileyo. Mov Disord 2019;34:950-8.
5. Merola A, Torres-Russotto DR, Stebbins GT, Vizcarra JA, Shukla AW, Hassan A, et al. Uphuhliso kunye nokuQinisekiswa kwe-Orthostatic Tremor Ubunzima kunye neSikali soKhubazeko (OT-10). Mov Disord 2020;35:1796-801.